Polymorphisms of the TAP2 transporter gene in systemic lupus erythematosus.

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چکیده

منابع مشابه

Polymorphisms of the TAP2 transporter gene in systemic lupus erythematosus.

OBJECTIVES To determine whether the TAP2 transporter gene, which lies between HLA-DP and HLA-DQ, is involved in determining susceptibility to systemic lupus erythematosus (SLE). METHODS TAP2 types were determined by ARMS-PCR in 89 white patients with SLE and 156 control subjects. RESULTS No particular TAP2 dimorphism or allele was associated with SLE or with any clinical/immunological subgr...

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p21 gene polymorphisms in systemic lupus erythematosus.

OBJECTIVE Cyclin-dependent kinase inhibitor 1A (p21) is a negative regulator in the cell cycle. Development of sex-linked lupus-like syndrome in p21-/- mice and reduced p21 gene expression in patients with systemic lupus erythematosus (SLE) compared with those in healthy controls suggested that p21 is a susceptibility gene of SLE. We investigated the same by a case-control association study. ...

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Neurobrucellosis in systemic lupus erythematosus

Background: Brucellosis is a zoonotic infection which is endemic in many countries. It is a multisystem disease which may present with a broad spectrum of clinical manifestations and complications. Neurobrucellosis is an uncommon complication of brucellosis. Case presentation: A 25-year-old woman with a history of lupus for 5 months referred to the emergency ward of Shahid Beheshti Hosp...

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CONCISE REPORT TAP1 and TAP2 polymorphisms analysis in northwestern Colombian patients with systemic lupus erythematosus

Objective: To determine the influence of TAP1 and TAP2 alleles in northwestern Colombian patients with systemic lupus erythematosus (SLE). Methods: Unselected patients with SLE (n=140) and controls (n=120) matched for sex, age, and ethnicity were analysed. Clinical manifestations, clinical activity, and severity of disease were recorded. Autoantibodies were detected by enzyme linked immunosorbe...

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Oestrogen receptor a gene polymorphisms in systemic lupus erythematosus

Objective: To analyse associations of two oestrogen receptor a (ORa) gene polymorphisms in 260 patients with SLE from northern Sweden. The two polymorphisms, PvuII T/C and the XbaI A/G, are located in the first intron of the ORa gene. Methods: All patients fulfilling at least four of the ACR criteria for SLE were consecutively recruited during one year. The SLEDAI score and SLICC damage index w...

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ژورنال

عنوان ژورنال: Annals of the Rheumatic Diseases

سال: 1994

ISSN: 0003-4967

DOI: 10.1136/ard.53.1.61